Cell kinetic analysis in pediatric brain and spinal tumors: a study of 117 cases with Ki-67 quantitation and flow cytometry.
Identifieur interne : 005654 ( Main/Exploration ); précédent : 005653; suivant : 005655Cell kinetic analysis in pediatric brain and spinal tumors: a study of 117 cases with Ki-67 quantitation and flow cytometry.
Auteurs : V. Jay [Canada] ; D. Parkinson ; L. Becker ; F W ChanSource :
- Pediatric pathology [ 0277-0938 ]
English descriptors
- KwdEn :
- Brain Neoplasms (classification), Brain Neoplasms (immunology), Brain Neoplasms (pathology), Cell Cycle, Flow Cytometry, Humans, Ki-67 Antigen, Neoplasm Proteins (analysis), Nuclear Proteins (analysis), Spinal Cord Neoplasms (classification), Spinal Cord Neoplasms (immunology), Spinal Cord Neoplasms (pathology).
- MESH :
- chemical , analysis : Neoplasm Proteins, Nuclear Proteins.
- chemical : Ki-67 Antigen.
- classification : Brain Neoplasms, Spinal Cord Neoplasms.
- immunology : Brain Neoplasms, Spinal Cord Neoplasms.
- pathology : Brain Neoplasms, Spinal Cord Neoplasms.
- Cell Cycle, Flow Cytometry, Humans.
Abstract
We present cell kinetic data including Ki-67 quantitation and flow cytometry on 117 pediatric brain/spinal cord tumors and review the literature. Although, in general, these proliferation indices are in agreement with the histologic grade, they are useful in prognostication in some instances when the histological features of malignancy are equivocal. Specific examples in which flow cytometry may prove particularly useful in this context are childhood ependymomas, which do not show frank anaplasia but have cellular foci with focal increase in mitoses, and choroid plexus neoplasms, where elevated S phase fractions have been associated with an adverse outcome. Thus Ki-67 quantitation and flow cytometry not only serve as useful adjuncts to conventional histologic grading but also in specific instances may provide new information on tumor prognosis.
PubMed: 8008689
Affiliations:
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Parkinson</name></author><author><name sortKey="Becker, L" sort="Becker, L" uniqKey="Becker L" first="L" last="Becker">L. Becker</name></author><author><name sortKey="Chan, F W" sort="Chan, F W" uniqKey="Chan F" first="F W" last="Chan">F W Chan</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="????"><PubDate><MedlineDate>1994 Mar-Apr</MedlineDate></PubDate></date><idno type="RBID">pubmed:8008689</idno><idno type="pmid">8008689</idno><idno type="wicri:Area/PubMed/Corpus">001979</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001979</idno><idno type="wicri:Area/PubMed/Curation">001979</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001979</idno><idno type="wicri:Area/PubMed/Checkpoint">001979</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001979</idno><idno type="wicri:Area/Ncbi/Merge">002446</idno><idno type="wicri:Area/Ncbi/Curation">002446</idno><idno type="wicri:Area/Ncbi/Checkpoint">002446</idno><idno type="wicri:doubleKey">0277-0938::Jay V:cell:kinetic:analysis</idno><idno type="wicri:Area/Main/Merge">006071</idno><idno type="wicri:Area/Main/Curation">005654</idno><idno type="wicri:Area/Main/Exploration">005654</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Cell kinetic analysis in pediatric brain and spinal tumors: a study of 117 cases with Ki-67 quantitation and flow cytometry.</title><author><name sortKey="Jay, V" sort="Jay, V" uniqKey="Jay V" first="V" last="Jay">V. Jay</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, Hospital for Sick Children-University of Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pathology, Hospital for Sick Children-University of Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Parkinson, D" sort="Parkinson, D" uniqKey="Parkinson D" first="D" last="Parkinson">D. Parkinson</name></author><author><name sortKey="Becker, L" sort="Becker, L" uniqKey="Becker L" first="L" last="Becker">L. Becker</name></author><author><name sortKey="Chan, F W" sort="Chan, F W" uniqKey="Chan F" first="F W" last="Chan">F W Chan</name></author></analytic><series><title level="j">Pediatric pathology</title><idno type="ISSN">0277-0938</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Brain Neoplasms (classification)</term><term>Brain Neoplasms (immunology)</term><term>Brain Neoplasms (pathology)</term><term>Cell Cycle</term><term>Flow Cytometry</term><term>Humans</term><term>Ki-67 Antigen</term><term>Neoplasm Proteins (analysis)</term><term>Nuclear Proteins (analysis)</term><term>Spinal Cord Neoplasms (classification)</term><term>Spinal Cord Neoplasms (immunology)</term><term>Spinal Cord Neoplasms (pathology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Neoplasm Proteins</term><term>Nuclear Proteins</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Ki-67 Antigen</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Brain Neoplasms</term><term>Spinal Cord Neoplasms</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Brain Neoplasms</term><term>Spinal Cord Neoplasms</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain Neoplasms</term><term>Spinal Cord Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Cell Cycle</term><term>Flow Cytometry</term><term>Humans</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We present cell kinetic data including Ki-67 quantitation and flow cytometry on 117 pediatric brain/spinal cord tumors and review the literature. Although, in general, these proliferation indices are in agreement with the histologic grade, they are useful in prognostication in some instances when the histological features of malignancy are equivocal. Specific examples in which flow cytometry may prove particularly useful in this context are childhood ependymomas, which do not show frank anaplasia but have cellular foci with focal increase in mitoses, and choroid plexus neoplasms, where elevated S phase fractions have been associated with an adverse outcome. Thus Ki-67 quantitation and flow cytometry not only serve as useful adjuncts to conventional histologic grading but also in specific instances may provide new information on tumor prognosis.</div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Ontario</li></region><settlement><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><noCountry><name sortKey="Becker, L" sort="Becker, L" uniqKey="Becker L" first="L" last="Becker">L. Becker</name><name sortKey="Chan, F W" sort="Chan, F W" uniqKey="Chan F" first="F W" last="Chan">F W Chan</name><name sortKey="Parkinson, D" sort="Parkinson, D" uniqKey="Parkinson D" first="D" last="Parkinson">D. Parkinson</name></noCountry><country name="Canada"><region name="Ontario"><name sortKey="Jay, V" sort="Jay, V" uniqKey="Jay V" first="V" last="Jay">V. Jay</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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